In On Bypass: Advanced Perfusion Techniques, editors Linda Mongero and James Beck have distilled the complex field of extrac- poreal circulation and intraoperative mechanical support down to its most basic and important components. By identifying the critical pieces of the complex puzzle that is cardiopulmonary bypass and having these presented by a truly all star cast of contributing authors, On Bypass represents a comprehensive, in depth compilation of the current sta- of the art in cardiopulmonary bypass technology and techniques. In chapters dedicated to engineering, cannulation, blood flow, prime solutions, and ultrafiltration, the reader is exposed to detailed descr- tions of the foundations of cardiopulmonary bypass technology. Other chapters illuminate the nuances of perfusion in special situations, such as pediatric, minimally invasive, and aortic surgery. Extension of ext- corporeal support beyond the operating room is covered expertly in a chapter on EeMO and long term pulmonary support. But this book goes beyond the traditional boundaries of a perfusion manual, and it is significantly strengthened by clinically oriented chapters dedicated to separation from cardiopulmonary bypass, the inflammatory response, and echocardiography. Finally, the editors draw upon their more than 50 years of experience as cutting edge perfusionists in a chapter on policies and procedures, which constitutes required reading for anyone managing a perfusion program. In sum, On Bypass represents an authoritative compendium of the most recent and best knowledge in every area relevant to cardiopul- nary bypass and perfusion.