This handbook explores ways to unify the study and application of adverse childhood experiences (ACEs) across multiple fields and disciplines, including clinical child and adolescent psychology, school psychology, pediatrics, social work, public health, education, and other health and human services. The book outlines a cohesive framework that organizes critical ACEs concepts throughout individual chapters, highlighting key issues and themes across settings and disciplines as well as gaps in current knowledge. Chapters examine interdisciplinary and collaborative approaches to ACEs and their impact on health and well-being within a specific topic area or setting. In addition, chapters review the foundations and development of the relevant science and provide examples of ACEs research and intervention applications as well as suggestions for continued advancement in this field. Key areas of coverage include: Definition and measurement of ACEs. Theory and models guiding ACEs research and practice. Applications of ACEs science across settings, including healthcare, mental and behavioral health, schools, justice system, and child welfare system. Applications of ACEs to public health and policy issues. Prevention strategies and policy approaches to ACEs. Handbook of Adverse Childhood Experiences is an essential resource for researchers, professors, and graduate students as well as clinicians and related mental health and medical therapists and professionals in developmental and clinical child and adolescent psychology, school psychology, child and adolescent psychiatry, social work, child and family studies, public health, pediatrics, and all interrelated disciplines.