This book provides a broad, detailed, and up-to-date approach to weaning from mechanical ventilation, offering readers insights into basic physiology, ventilation modes, and the spontaneous breathing test. It also delves into modern tools such as ultrasound, inspiratory muscle training, and AI applications in weaning. Additionally, it covers non-invasive mechanical ventilation, sedation, and weaning in special populations, including patients with COPD, cardiopathy, neurological conditions, and those affected by COVID-19. Key concepts explored include the physiological underpinnings of weaning, the latest advancements in ventilation technology, and the integration of physiotherapy techniques. The book addresses critical questions such as how to optimize weaning protocols and improve patient outcomes. Contributions from experienced practitioners and scholars provide a thorough analysis of current practices and emerging trends, making this book a must-read for those seeking to enhance their understanding and skills in critical care. Weaning from Mechanical Ventilation – A State-of-the-Art Approach is an indispensable resource for physicians, physiotherapists, respiratory therapists, nurses, and anyone involved in the management of patients requiring mechanical ventilation. It is designed to equip healthcare professionals with the knowledge needed to improve patient outcomes and enhance critical care practice.