The importance of a professionally and practically appropriate healthcare system for people with chronic illnesses—especially those with multiple chronic conditions—is undeniable in light of demographic changes and the increasing number of older adults with limited everyday competence. Although the German Enquete Commission on "Demographic Change" identified requirements and proposed solutions as far back as thirty years ago, there are still significant gaps in both scientific research and practical healthcare provision. This handbook aims to help close these gaps. It brings together various professional perspectives, highlights the interfaces and tools for collaboration among the different professional groups and healthcare institutions involved in care, and presents methods for care planning and development across diverse care settings and arrangements. Therefore, the handbook is suitable for practitioners involved in direct patient care as well as for those engaged in healthcare planning. At the same time, it is intended for students, researchers, and educators in the field of Chronic Care Sciences and related disciplines, such as medicine, nursing, therapy sciences, social sciences, and social work.